Manganese and calcium efflux kinetics in brain mitochondria. Relevance to manganese toxicity
نویسندگان
چکیده
منابع مشابه
Relevance to manganese toxicity
Manganese shares the uniport mechanism of mitochondrial calcium influx, accumulates in mitochondria and is cleared only very slowly from brain. Using dual-label isotope techniques, we have investigated both Mn2" and Ca2" mitochondrial efflux kinetics. We report that (1) there is no significant Na+-dependent Mn2" efflux from brain mitochondria; (2) Mn2" inhibits both Na+-dependent and Na+-indepe...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1990
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2660329